Targeting Cancer Stem Cells and Metastasis with Epigenetic Modulation and Anti-HER2 Therapy: Phase I/II Trial of Vorinostat in Combination with Lapatinib
Targeting Cancer Stem Cells and Metastasis with Epigenetic Modulation and Anti-HER2 Therapy: Phase I/II Trial of Vorinostat in Combination with Lapatinib
Review Data
Purpose and Significance of Study: This is the report of a phase I/II clinical trial, containing very promising findings. Previous preclinical studies by the authors had showed that the pan histone deacetylase inhibitor vorinostat in combination with lapatinib significantly reduced the self-renewal capacity of cancer stem cells (CSCs) and prevented metastasis. The results of this trial show that this combination is safe and effective in HER-2 positive breast cancer. However, the study is limited by its small sample size (12). Nevertheless, the results indicate the need for novel clinical trial endpoint and correlative studies in order to assess new investigational agents targeting the CSC population.
Fit with Scope of Journal: The manuscript is of very high interest for the journal Clinical Oncology and Research.
The results are very clearly described, supported by the data. The Discussion aptly covers the implications of the findings and lays down the direction of future research in this area.
o The manuscript contains a few minor errors (already corrected in the galley proof, except the major highlighted one, which requires the author’s attention) listed below –
· The figures, including supplemental figures are missing.
· In the 3rd sentence in the Results in the Abstract, “the” before “phase I” must be replaced with “in”, and in the next sentence, “positve” must be replaced with “positive”.
· In the 1st sentence of the Statement of Significance, “,” after “CSCs” must be replaced with “’”.
· In the 2nd sentence of Phase II cohort in Patient selection in the Materials and Methods, “providing” must be replaced with “provided”.
Amanda Schech
Angela Brodie
Jane Lewis
Katherine Tkaczuk
Martin J. Edelman
Nancy Tait
Saranya Chumsri
Ting Bao
Vered Stearns
Author Info
Corresponding Author
Saranya Chumsri
Department of Hematology/Oncology, Mayo Clinic, Jacksonville, Florida, USA
Article Info
Article Type
Research Article
Publication history
Received: Fri 29, May 2020
Accepted: Sun 28, Jun 2020
Published: Sat 04, Jul 2020
Copyright
© 2023 Saranya Chumsri. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.COR.2020.07.04