Integrative Analysis of HMMR as a Potential Target of Prognosis and Therapy in Hepatocellular Carcinoma

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for

researchers?

A: Excellent

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Very good

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Very good

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Good

Tools and Methods

Q: Are methods the author uses adequate and well used?

A: Very good

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Good

Comments:

The Results are consistent with previous reports demonstrating the prognostic impact of hyaluronic acid-mediated motor receptor (HMMR) on hepatocellular carcinoma (HCC). The research work is adequately supported with statistical data and figures. The Conclusion section summarizes that higher expression of HMMR predicts higher invasiveness and poorer prognosis of hepatocellular carcinoma and might be used as a candidate for tumor efficacy evaluation. Further study is needed to validate the biological functions of HMMR on the pathogenesis of tumors.

Literature

Q: Does the author utilize relevant literature?

A: Very good

Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Very good

Length

Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Very good

Writing style

Q: Is it clear and understandable?

A: Good

Further comments on the paper

Comments: The study focuses on the underlying effect of hyaluronic acid-mediated motor receptor in the development and prognosis of hepatocellular carcinoma. The study holds significance as HMMR plays an important role in regulating tumor metastasis. However, the clinical significance of HMMR and its underlying mechanisms for regulating hepatocellular carcinoma (HCC) is still poorly understood and research on HMMR as a prognostic marker for HCC is still limited. The relationship between HMMR expression and prognostic value in 407 patients with HCC in the TCGA datasets has been well analysed in this study.

Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

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Science Repository Team