Primary Testicular Non-Hodgkin Lymphoma: A Retrospective Single Centre Experience of 26 Cases with Long Follow Up

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for

researchers?

A: Excellent

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Very good

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Good

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Very good

Tools and Methods

Q: Are methods the author uses adequate and well used?

A: Good

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Good

Comments:

The study confirms that advanced Ann-Arbor stages (III/IV) are markers of poor prognosis for primary testicular lymphoma in Austria. The Discussion explains the challenges in treating the patient in the present case clearly. It also offers useful suggestions with respect to the treatment regimen. The study Concludes that survival is different in early stages I/II versus advanced stages III- IV of the disease. Due to the rarity of primary testicular lymphoma and the lack of prospective trials, prospective multi-center studies with large number of cases are recommended.

Literature

Q: Does the author utilize relevant literature?

A: Very good

Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Good

Length

Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Very good

Writing style

Q: Is it clear and understandable?

A: Very good

Further comments on the paper

Comments: This retrospective study reviews the clinical data of 26 patients and analyses the clinical characteristics, therapy and survival outcomes of patients with primary testicular lymphoma from 1998 to 2017 and compares differences in survival based on Ann Arbor Stages. Primary testicular lymphoma is a rare and aggressive malignancy representing 1% to 2% of all non-Hodgkin lymphomas (NHL) and accounts for approximately 5% of all testicular tumors. The retrospective nature of the study, the single center experience and the small number of patients come out as some of the limitations of this study.

Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

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