Correlative Analysis of Massive Epistaxis and Pseudoaneurysms in Nasopharyngeal Carcinoma after Radiotherapy and a 10-Year Review

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for

researchers?

A: Excellent

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Very good

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Good

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Very good

Tools and Methods

Q: Are methods the author uses adequate and well used?

A: Very good

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Good

Comments:

The Results clearly show that the formation of a pseudoaneurysm is closely associated with a high carcinoma stage, re-radiotherapy, and local bone destruction and infection. The Discussion puts forth the rationale for taking up the study, effectively describes the relevant literature and enlists the implications of the findings from the present study in that context. The Conclusion summarizes from the results of the study that a pseudoaneurysm occurring in patients with massive epistaxis after radiotherapy for nasopharyngeal carcinoma has a high probability with a unique characteristic of sentinel hemorrhage.

Literature

Q: Does the author utilize relevant literature?

A: Very good

Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Very good

Length

Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Very good

Writing style

Q: Is it clear and understandable?

A: Very good

Further comments on the paper

Comments: This retrospective review aims to analyze the characteristics and etiological factors of nasopharyngeal hemorrhage in post-irradiated nasopharyngeal carcinoma (NPC) patients and discusses the treatment strategy of endovascular treatment for carotid artery pseudoaneurysm. The study is of significance as nasopharyngeal carcinoma is a common malignant tumor of the nasopharynx, with a high incidence in Southeast Asia and southern China. The study reviews 21 patients with massive epistaxis after radiotherapy for NPC and reviews the literature over the past 10 years to analyze the characteristics and related causes of pseudoaneurysms in terms of the clinical stage of NPC, course of radiotherapy, affected artery, and endovascular interventional treatment of such pseudoaneurysms.

Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

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