Effects of MDR1 Gene Polymorphism on Efficacy and Hematotoxicity of Epirubicin-Based Regimen in Patients with Breast Cancer in Southwest China

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for

researchers?

A: Very good

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Very good

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Good

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Good

Comments:

A few minor errors have been noted in the manuscript:

• In Materials and Methods, the word “forward” has been misspelt under the subheading “The primer design of MDR1 gene SNP” throughout.
• In the 2^nd sentence under “Statistical Analysis”, “clinical basic characteristics” should be reframed as “basic clinical characteristics”.
• In the 10^th sentence of first paragraph of Discussion, the words “affects” and “attribute” should be changed to “affect” and “attributed” respectively.

·       The heading “Conclussion” should be corrected to “Conclusion”.

Tools and Methods

Q: Are methods the author uses adequate and well used?

A: Very good

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Very good

Comments:

The Results are clearly explained and aptly supported by data. The study is well-executed, and the Conclusion provides an apt summary of the findings of the present study. It suggests that C3435T polymorphism may be a risk factor for grade III ~ IV leukopenia in breast cancer patients treated with Epirubicin regimen in Southwest China. Confirmation of the results are further required by large sample, multicenter clinical studies.

Literature

Q: Does the author utilize relevant literature?

A: Very good

Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Good

Length

Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Excellent

Writing style

Q: Is it clear and understandable?

A: Good

Further comments on the paper

Comments: The study investigates the predictive value of multi-drug resistance gene (MDR1) polymorphism in the efficacy and hematological toxicity of chemotherapy regimen based on Epirubicin in patients with breast cancer in Southwest China. The fact that the incidence of breast cancer is ranked first place as a deadly disease among female cancer patients, makes the study significant. It includes patients who have received Epirubicin-based chemotherapy, and polymorphism of C1236T, G2677T/A and C3435T were detected by time-of-flight mass spectrometry (TOF-MS).

Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

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Thanks,
Science Repository Team