The Potential of U6 and Its Copies in the Regulation of the Human Genome

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for

researchers?

A: Very good

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Excellent

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Good

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Very good

Tools and Methods

Q: Are methods the author uses adequate and well used?

Comments:

Not Applicable.

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Very good

Comments:

The Introduction lays down the basics for taking up the present study. This review article encompasses the relevant findings from the previous studies on U6 and other snRNAs and provides a thorough analysis of the findings and their implications. The Conclusion section summarizes from the study of literature that U6 is undoubtedly an snRNA with essential functions in the human genome, since during evolution it has considerably increased its number of copies and variants in the human genome.

Literature

Q: Does the author utilize relevant literature?

A: Good

Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Good

Length

Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Very good

Writing style

Q: Is it clear and understandable?

A: Very good

Further comments on the paper

Comments: This review article discusses the importance of U6 together with other snRNAs, to carry out the catalytic activity and recognition of annealing target sequences, its evolution in the genome and the fact that the genome has many U6 copies and pseudogenes, its association with retrotransposition, as well as their implication in diseases. U6, which is one of the four snRNAs forming the spliceosome, has been extensively studied. This study aptly recommends further studies to understand the function, if any, of each of these copies and pseudogenes as only a few U6 copies have been identified to date as potentially active genes.

Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

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Science Repository Team