Comparison Between CT Volumetric Measurement and RECIST 1.1 Criteria to Assess the Tumoral Response in Advanced Renal Cell Carcinoma Treated by Immunotherapy

Review Data

Q: Is the topic relevant to the journal's area of interest? Is it contemporary and interesting for

researchers?

A: Good

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Good

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Good

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Good

Tools and Methods

Q: Are the methods the author uses adequate and well used?

A: Good

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Good

Comments: The Discussion illustrates the comprehensive retrospective study conducted for the research providing relevant literature. The authors compared the previous reports with the results of the study and evaluated the reproducibility of the volumetry. Further, the Discussion puts forth the limitations of the research. The Conclusion summarizes that inter-observer reproducibility of the volumetric method is higher than RECIST measurements in advanced renal cancer.

Literature

Q: Does the author utilize relevant literature?

A: Good

Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Good

Length

Q: Is the paper's length adequate to the topic's significance? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Good

Writing style

Q: Is it clear and understandable?

A: Good

Further comments on the paper

Comments: The manuscript establishes a retrospective comparison between the volumetric method versus gold standard unidimensional measurement based on RECIST 1.1 to assess the tumoral response in advanced renal cell carcinoma treated by immunotherapy. The research gave a detailed account of the population, CT acquisition, target lesion measurements, response assessment and statistical analysis.

Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

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Science Repository Team