Clinical and Prognostic Analysis of Adult Acute Lymphoblastic Leukemia

Review Data

Q: Is the topic relevant to the journal's area of interest? Is it contemporary and exciting for researchers?

A: Good

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Good

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Very Good

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Good

Tools and Methods

Q: Are the methods the author uses adequate and well used?

A: Good

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them coherent?

A: Very Good

Comments: The Discussion gives an overview of acute lymphoblastic leukemia (ALL) and suggests early risk stratification in the determination of prognosis and treatment strategy. The authors also discussed the origin of adult ALL and the research was carried out taking into consideration different age groups. The authors recommended Allo-HSCT during CR1 for patients highly likely to suffer from recurrence. The Conclusion illustrates that adult ALL patients are more prone to relapse after remission and have poor long-term survival.

Literature

Q: Does the author utilize relevant literature?

A: Good

Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Good

Length

Q: Is the length of the paper adequate for the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legends and notations clear?

A: Good

Writing style

Q: Is it clear and understandable?

A: Good

Comments: There are few errors found in the manuscript, which are as follows:

·       Under Introduction, 4^th paragraph, 2^nd sentence, “Exploring factors affecting… formulate individualized strategy…” should be written as “Exploring factors affecting… formulate individualized strategies…”.

·       Under heading, statistical analysis, 1^st sentence, “Chi-square test or Fisher exact test… treating effects” is rewritten as “Chi-square test or Fisher exact test… treating effects” is rewritten as “Chi-square test or Fisher exact test… treatment effects”.

·       In Discussion, 1^st paragraph, 3^rd sentence, “Early risk stratification is helpful to determine outcome and guide treating strategy” must be written as “Early risk stratification is helpful in determining outcome and guide treatment strategy”.

Further comments on the paper

Comments: The research analysed and illustrated the clinical characteristics of 65 adult patients diagnosed with acute lymphoblastic leukemia (ALL) and put forth the prognostic factors to provide evidence for the stratification of prognostic risk and the formulation of the individualized therapy. The study has elucidated the overall patient data, treatment strategy, and efficacy of evaluation. The results also described the statistical and survival analysis of the patient data and screened out the valuable predictive factors.

Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

If you have any questions or clarifications you can write to the journal.

Thanks,
Science Repository Team