Almorexant, an Orexin Antagonist with Anti-Tumoral Properties in Human Colon Cancer

Review Data

 

Purpose and Significance of Study: This study investigated the anti-tumoral role of the small molecule analog and orexin antagonist, almorexant, in colon cancer. The anti-tumoral effect of almorexant was possibly mediated by orexin receptor 1. The finding poses almorexant as a putative candidate for the treatment of colorectal cancer, one of the most prevalent of cancers.

 

Fit with Scope of Journal: The manuscript is of very high interest for the journal European Journal of Molecular Cancer.

 

In the discussion, the authors have elaborated the anti-tumoral effect of almorexant on the HT-29 colon cancer cell line, compared that to the effect of orexin, discussed the possible pathway of action, and also its effect in a preclinical model, all of which contributes to the potential therapeutic implications of almorexant in colorectal cancer.

 

The manuscript contains a few minor errors (already corrected in the galley proof), which are listed below –

 

·       Using incorrect tense, e.g., “led” after “prostaglandins” in the 10^th sentence of the Introduction must be replaced with “lead”, “produced” in the 12^th sentence of the same paragraph must be replaced with “produces”, and so on.

·       Using “to” and “of” instead of “on” after “depend” and “with” after “associate” on multiple occasions.

·       In the 7^th sentence of Almorexant induced a mitochondrial apoptosis in colonic cancer cell line HT-29 in the Results and Discussion, “discriminate” must be replaced with “distinguish”.

Author Info

S. Dayot V. Gratio P. Nicole T. Voisin Alain Couvineau

Corresponding Author

Alain Couvineau
INSERM UMR1149/ Inflammation Research Center (CRI), Team “From inflammation to cancer in digestive diseases” labeled by “la Ligue Nationale Contre le Cancer”, University of Paris, DHU UNITY, Paris, France

Article Info

Article Type

Research Article

Publication history

Received: Thu 23, Apr 2020
Accepted: Mon 08, Jun 2020
Published: Fri 24, Jul 2020

Copyright

© 2023 Alain Couvineau. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.EJMC.2020.01.02