Exogenous Hydrogen Sulfide Alleviated Left Ventricular Fibrosis Via Enhancing Cardiac Autophagy and Decreasing Cardiomyocyte Apoptosis in StreptozotocinInduced Diabetic Rats: From Network Pharmacology to Experimental Pharmacology

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for

researchers?

A: Excellent

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Excellent

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Excellent

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Good

Tools and Methods

Q: Are methods the author uses adequate and well used?

A: Very good

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Excellent

Comments:

The Discussion section aptly summarizes the observations of the study with the help of relevant literature. It highlights the therapeutic potential of H₂S in alleviating cardiac function, enhancing autophagy and inhibiting cardiomyocyte apoptosis by inactivating the ERK1/2 pathway in Streptozotocin (STZ)-induced diabetic rat models associated with cardiac injury. It also discusses the role of network pharmacology to assess the possible mechanisms of actions of drug on a specific target with the help of various databases.

Literature

Q: Does the author utilize relevant literature?

A: Very good

Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Very good

Length

Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Very good

Writing style

Q: Is it clear and understandable?

A: Good

Further comments on the paper

Comments: This study provides a valuable insight into the cardioprotective role of H₂S in Streptozotocin (STZ)-induced diabetic rat models. Network pharmacology method enables the identification of a set of potential drugs and their targets, the drug target interactions and the pathways responsible for their mechanisms of actions. The predicted targets and pathways were validated by in vivo experiments. Diabetes mellitus (DM) develops diabetic cardiomyopathy (DCM) in presence of STZ which induces apoptosis of cardiomyocyte and suppresses cardiac autophagy. The analysis of this study implies that exogenous H₂S has anti-diabetic cardiomyopathy effects. H₂S appears to be a potent therapeutic drug as it enhances autophagy, inhibits cardiomyocyte apoptosis, alleviates myocardial hypertrophy and improves cardiac function by relieving cardiac fibrosis.

Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

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