Oral Squamous Cell Carcinomas in Patient with Graft Versus-Host Disease Following Allogenic Bone Marrow Transplantation: A Case Report during Mutant COVID-19 Pandemic

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for

researchers?

A: Good

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Good

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Good

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Good

Tools and Methods

Q: Are methods the author uses adequate and well used?

A: Good

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Good

Comments: The Discussion elaborates the risk factors and time of occurrence of the secondary cancers after haematopoietic stem cell transplantation (HSCT), providing relevant literature. The case brings forth a comparison with that of the reported cases in literature. Finally, the Discussion summarizes by highlighting that known connection between graft versus host disease (GvHD) of oral cavity mucosa and oral squamous cell carcinoma (OSCC) should be a warning to doctors to pay attention to closer follow-up and the biopsy of suspected lesions.

Literature

Q: Does the author utilize relevant literature?

A: Good

Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Good

Length

Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Good

Comments: In Table 2, the keynote for “#” is not provided.

Writing style

Q: Is it clear and understandable?

A: Good

Comments: In Case Report, 1^st paragraph, 6^th sentence, “In December 18, 2017” must be written as “On December 18, 2017”.

Further comments on the paper

Comments: This Case Report presents a 30-year-old woman with complications of chronic graft versus host disease (cGvHD) and oral squamous cell carcinoma (OSCC) after few months of haematopoietic stem cell transplantation (HSCT). This illustrates the association between oral cGvHD and OSCC and the potential appearance of OSCC after HSCT at any time of patient life. This report describes the overall treatment of aplastic anaemia (AA), and later on, the management of cGvHD and OSCC.

Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

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Science Repository Team