Morphological Characteristics of Aortic Stenosis in Familial Hypercholesterolemia and Non-Familial Hypercholesterolemia in the Elderly

Review Data

Purpose and Significance of Study: This is a study on the morphological characteristics of aortic stenosis in familial hypercholesterolemia and non-familial hypercholesterolemia in the elderly population, conducted on 24 subjects in Japan. 

 

Fit with Scope of Journal: The manuscript is of high interest for the Journal of Integrative Cardiology Open Access.  

 

o   A few corrections (already incorporated in the galley proof, except the highlighted one which requires the author’s attention) in the manuscript are listed below – 

In the Title – 

·       “Morphologic” must be replaced with “morphological”. 

In the Abstract – 

  In the 1^st paragraph – 

·       In the 2^nd sentence, “have been also” must be replaced with “has also been”. 

  Under Results – 

·       In the 2^nd sentence, “younger” must be replaced with “less”. 

·       In the 3^rd sentence, “were infiltrated on” must be replaced with “infiltrated”. 

·       In the 4^th sentence, “macrophages” must be replaced with “macrophage”, and “were” must be replaced with “was”. 

  Under Conclusion – 

·       In the 2^nd sentence, “of” after “different” must be replaced with “from”, “related” must be removed, and “long termed” must be replaced with “long-term”. 

In the Introduction – 

  In the 1^st paragraph – 

·       In the 2^nd sentence, “other four” must be replaced with “four other”, and “abnormalities in the” must be inserted before “LDLR adapter protein 1”. 

  In the 2^nd paragraph – 

·       In the 4^th sentence, “factor” must be inserted after “risk”. 

In the Subjects and Methods – 

  Under Subjects – 

·       In the 1^st sentence, “3” must be replaced with “three”, “level” must be replaced with “levels”, “time” must be removed, and “who” must be inserted before “underwent”. 

  Under Methods – 

  Under Echocardiographic Findings – 

·       At the end, “Netherland” must be replaced with “the Netherlands”. 

  Under Computed Tomography – 

·       The 1^st sentence must be replaced with “CT of the aorta and heart were performed in some cases”, “Canon Medial Systems” must be replaced with “Canon Medical Systems”. 

·       In the 2^nd sentence, “calcium degree” must be replaced with “degree of calcification”. 

  Under Pathological Findings – 

  Under Gross pathology – 

·       In the 1^st sentence, “thickening” must be replaced with “thickness”. 

  Under Pathological analysis by routine histology – 

·       In the 2^nd sentence, “none; 0, 1, mild; 2, moderate; and 3, high” must be replaced with “0: none, 1: mild, 2: moderate, and 3: high”. Same goes for the 3^rd sentence. 

  Under Statistical Analysis – 

·       “;” must be inserted after “continuous variable”, and “for” after that must be removed. 

In the Results – 

  Under Comparison of AS lesions between FH and non-FH patients – 

  Under Comparison of pathological findings of aortic valves of Ho-FH, He-FH, and non-FH – 

  In the 1^st paragraph – 

·       In the 2^nd sentence, “were observed” must be removed. 

  In the 2^nd paragraph – 

·       In the 1^st sentence, “calcific” must be replaced with “calcified”. 

In the Discussion – 

  In the 1^st paragraph – 

·       “with” after “compared” must be replaced with “to”. 

  In the 2^nd paragraph – 

·       In the 3^rd sentence, “of” before “patients” must be replaced with “in”, and “composed of” must be replaced with “had”. 

  In the 4^th paragraph – 

·       In the 2^nd sentence, “calcium amount” must be replaced with “The calcification”. 

  In the last paragraph – 

·       This sentence is about a limitation of the study; hence it must be included under the heading “Limitations of the study” instead. 

In the Limitations of the study – 

·       In the 3^rd sentence, “patient” must be replaced with “patients”, and “statin” must be replaced with “statins”. 

Author Info

Hatsue Ishibashi-Ueda Mariko Harada-Shiba Michio Noguchi Mika Hori Naotaka Ohta Tomoyuki Fujita Tsutomu Tomita

Corresponding Author

Hatsue Ishibashi-Ueda
Department of Pathology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan

Article Info

Article Type

Research Article

Publication history

Received: Tue 17, Mar 2020
Accepted: Sat 04, Apr 2020
Published: Mon 13, Apr 2020

Copyright

© 2023 Hatsue Ishibashi-Ueda. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.JICOA.2020.02.03