Bi-Ventricular Myocardial Performance in Heart Failure: A New Approach to Evaluate Interventricular Dyssynchrony

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for

researchers?

A: Very good

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Very good

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Very good

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Good

Tools and Methods

Q: Are methods the author uses adequate and well used?

A: Good

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Very good

Comments:

The Discussion is well supported with the observations and it thoroughly explains the results and their implications. The limitations of this study are also properly addressed in this section. Figures and tables are briefly explained.

Literature

Q: Does the author utilize relevant literature?

A: Good

Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Very good

Length

Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Very good

Writing style

Q: Is it clear and understandable?

A: Very good

Further comments on the paper

Comments: This preliminary study, involving 40 Caucasian patients with New York Heart Association (NYHA) functional class II to III, chronic heart failure of any origin, reports for the first time that myocardial performance index (MPI) is neither only a measure of intrinsic systolic nor only of diastolic disease, but it also reflects the secondary effects of abnormal activation related to the degree of energy loss results from in-coordinated LV contraction and therefore it could be an easily reproducible and adjunctive index and a new parameter to diagnose interventricular dyssynchrony and screen candidates for cardiac resynchronization therapy (CRT). However, very small sample size is the main limitation of this study and the evaluation of ∆MPI as a better index of ventricular dyssynchrony requires further research. Few modifications are required in the manuscript due to high plagiarism score that is 21%.

Q: Would you recommend this manuscript for further publication?

A: Corrections - Suitable for publishing after corrections

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