Albutate-1, a Novel Long-Circulating Radiotracer Targeting the Somatostatin Receptor Subtype 2

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for

researchers?

A: Very good

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Very good

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Good

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Very good

Tools and Methods

Q: Are methods the author uses adequate and well used?

A: Very good

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Excellent

Comments: The Discussion section provides an apt analysis of the optimization of the therapeutic efficacy of the radiotracer Albutate1, conjugated with DOTA-TATE which prolongs the blood circulation time of the radiotracer to further improve the tumor uptake and the treatment of neuroendocrine tumors (NET). The Conclusion establishes the potential of albumin-binding entities which help in identifying the target somatostatin receptor subtype 2 (SSTR2) and in reducing the therapeutic index. Further investigation with increased dose and frequency is needed to determine the potential advantages of a longer circulating tracer.

Literature

Q: Does the author utilize relevant literature?

A: Very good

Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Very good

Length

Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Excellent

Writing style

Q: Is it clear and understandable?

A: Good

Further comments on the paper

Comments: This study demonstrates the significance of Albutate 1, a novel long-circulating albumin-binding radiotracer that is considered as pharmacokinetic modifiers in the treatment of neuroendocrine tumors (NET). It assesses the therapeutic efficacy of DOTA-TATE coupled with Albutate 1 which extends the blood circulation time of the tracer and increases tumor uptake which eventually reduces the therapeutic index. It calls for further research to create a tracer with more optimal pharmacokinetics by changing the albumin binding strength, spacer length and lipophilicity.

Q: Would you recommend this manuscript for further publication?

A: Yes- Suitable to be published

If you have any questions and clarifications you can write to the journal.

Thanks,
Science Repository Team