Proteomics Approach (iTRAQ) to Test Subchronic and Chronic Toxicity Effects of Mice Exposed to Drinking Water Source from Yangtze River Delta

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for

researchers?

A: Good

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Very good

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Good

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Good

Tools and Methods

Q: Are methods the author uses adequate and well used?

A: Very good

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Good

Comments:

The Discussion focusses on the four sections of the cellular process and function namely amino acids metabolism, cell skeleton (actins and microtubules) reorganization, apoptosis and cancer. The experiments are well supported with adequate figures and tables. The Conclusion section summarizes from the results of the study that the water used from Yangtze River Delta for drinking purposes can accelerate aging, enhance apoptosis and increase carcinogenesis risk.

Literature

Q: Does the author utilize relevant literature?

A: Good

Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Very good

Length

Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Very good

Writing style

Q: Is it clear and understandable?

A: Good

Further comments on the paper

Comments: The study aims to investigate the combined effects of the pollutants in source of drinking water from Yangtze River Delta for local populations, using mice models for testing the subchronic toxicity for three months and chronic toxicity for six months. The study holds significance as the Yangtze River is the main source of drinking water for cities located in southeast of China. Proteomics test, by the comparison of mice fed with distilled water and drinking water source from Yangtze River Delta has been presented here.

Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

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Thanks,

Science Repository Team