Therapeutic Efficacy Evaluation and Underlying Mechanisms Prediction of Jianpi Liqi Decoction for Hepatocellular Carcinoma

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for

researchers?

A: Very good

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Excellent

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Very good

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Good

Tools and Methods

Q: Are methods the author uses adequate and well used?

A: Very good

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Very good

Comments:

This study investigates the therapeutic effect of Jianpi Liqi decoction (JPLQD) combined with minimally invasive procedures in hepatocellular carcinoma (HCC), and performs an analysis of network pharmacology, combined with proteomics, to predict the effective mechanisms of JPLQD. The study is well designed and executed. The Methods and Results are adequately described. The Results are clearly explained and aptly supported by figures and data. The Discussion offers a thorough and detailed analysis of the findings of the present study taking all the relevant literature into account. The main purpose of traditional Chinese medicine (TCM) treatment is to protect liver, inhibit tumor growth, extend survival and improve the quality of life in patients. The Conclusion section summarizes from the results of the review that JPLQD prolonged survival improved the quality of life and reduced the side effects in HCC patients with conventional transcatheter arterial chemoembolization (cTACE) and radiofrequency ablation (RFA) treatment, indicating that it may be an anti-HCC and liver protective complementary medicine.

Literature

Q: Does the author utilize relevant literature?

A: Good

Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Very good

Length

Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Very good

Writing style

Q: Is it clear and understandable?

A: Very good

Further comments on the paper

Comments: This retrospective study aims to assess the therapeutic effects of Jianpi Liqi decoction (JPLQD) in hepatocellular carcinoma (HCC) and explore its underlying mechanisms. The strong side effects and low response rates, along with the emergence of drug resistance, present limitations in the treatment of HCC, therefore, there is an urgent need to develop new treatment strategies and therapeutic targets. This study holds significance as its results demonstrates that JPLQD comprehensive therapy can significantly improve the clinical symptoms of patients, reduce the side effects, improve the quality of life, and prolong overall survival (OS) and progression-free survival (PFS). Combination therapy provides a potential solution to tumor heterogeneity and drug resistance by utilizing several mechanisms of action of a variety of treatments.

Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

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Science Repository Team