Neurogenesis and Oligodendrogenesis in a Mouse Model of Blast-Induced Traumatic Brain Injury

Review Data

The Post Traumatic Stress Disorder (PTSD) like TBI particularly the blast-induced TBI is only recently been considered for interrogation and is of great relevance because of the emergence of modern warfare. Although it is now getting well known that SVZ and SGZ are active in neurogenesis, how this process is relevant to post traumatic recovery in the brain is still not established. The manuscript has addressed this question logically and carried out a systematic study using the mice model for TBI. The experimental plans are well defined and executed and meaningful data were obtained. The conclusion that SVZ and SGZ are generally spared in TBI, indicating preserving the stem cells population there and the post traumatic recovery if any is due to differentiation of the pre-existing NPC based on the data presented is very logical. They have also indicated in the discussion that post traumatic recovery seems misguided within the time frame used in this study. Therefore, a long-term follow-up will address that question more completely. 

However, as such the data are significant and suitable for publication if authors are able to address issue with Fig 1D explaining the level of significance in the appearance of Astrocytes between the Day 5 control group (sham-blast) and the Day 5 blast group. It will be more helpful to look at numbers here, on the basis of immunofluorescence.

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Science Repository Team