Bell’s Palsy May Associate with Increased IL1R1: A Pilot Novel Gene and lncRNA Study

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for

researchers?

A: Very good

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Excellent

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Very good

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Good

Comments:

Minor errors found in the manuscript (already corrected in the Galley Proof) are as follows:

• In the 1^st sentence of “Background” under Abstract, the word “caused” must be changed to “causes”.
• The term “Bell’ palsy” in Keywords must be corrected to “Bell’s palsy”.
• In the 1^st sentence under Introduction, “paralyzed of facial muscles” should be corrected to “paralyzed facial muscles”.
• In the 3^rd sentence of “RNA extraction and Illumina sequencing” under Methods, “RNA of from each sample” should be changed to “RNA from each sample” and in the 1^st sentence under “Identification of DEGs and DELs” the word “group” is present multiple times, so the extra ones should be removed.
• The term “mediumt confidence” should be corrected to “medium confidence”.
• Commas, articles and prepositions such as “a”, “the” were missing throughout the text.

Tools and Methods

Q: Are methods the author uses adequate and well used?

A: Very good

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Very good

Comments:

The study is well designed and executed. The Methods and Results are adequately described. The study is well supported with briefly explained figures and tables. The Discussion puts forth the rationale for taking up the study, effectively describes the relevant literature and enlists the implications of the findings from the present study in that context. In this study, IL1R1 was detected highly expressed in patients with Bell's palsy which indicated that IL1 might be involved in inflammation and immune regulation in the onset of Bell's palsy. The Conclusion is evident with the evidences presented in the article. The results of the study aptly indicate direction for further exploration in the future.

Literature

Q: Does the author utilize relevant literature?

A: Very good

Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Very good

Length

Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Very good

Writing style

Q: Is it clear and understandable?

A: Good

Further comments on the paper

Comments: The present study aims to search for potential influencing factors by identifying the key genes and long noncoding RNAs (lncRNAs) and their relevant networks involved in patients with Bell’s palsy using RNA-Seq data based on bioinformatics tools, which will be helpful to reveal the underlying mechanism of the onset of Bell's palsy. The study holds significance as Bell's palsy is a widespread disease of the peripheral nervous system and the etiological factor of Bell's palsy is still unclear. Detection of serum samples rather than tissue samples and no verification of the key differentially expressed lncRNAs (DELs) and differentially expressed genes (DEGs) expressions in Bell's palsy patients through experiment comes out as some of the limitations of the study.

Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

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Science Repository Team