Olfactory Stem Cells for the Treatment of Spinal Cord Injury: Isolation, Purification and Behaviour in a Plasma Clot Matrix
Olfactory Stem Cells for the Treatment of Spinal Cord Injury: Isolation, Purification and Behaviour in a Plasma Clot Matrix
Review Data
Purpose and Significance of Study: This study involved the isolation and purification of olfactory stem cells (OSCs) from human olfactory mucosa using the neurosphere assay, and characterization of the behavior of purified OSCs in an autologous three-dimensional cell carrier matrix plasma clot. The results strengthen the position of OSCs as a candidate for autologous transplantation in combination with the plasma clot as a cell carrier in spinal cord injury and neurodegenerative diseases.
Fit with Scope of Journal: The manuscript is of very high interest for the journal International Journal of Regenerative Medicine.
The Discussion puts forth the rationale for taking up the study, effectively describes the relevant literature, and enlists the implications of the findings from the present study in that context.
o The manuscript contains a few minor errors (already corrected in the galley proof), which are listed below –
· In the 1st sentence of the 2nd paragraph of the Introduction, “quiet” must be replaced with “quite”.
· In the 6th sentence of the 2nd paragraph of the Introduction, “neuronal” must be replaced with “neural”.
· In the 10th sentence of the 2nd paragraph of the Introduction, “stem cells” must be inserted after “embryonic”.
· In the 1st sentence of the 1st paragraph of Differentiation potential in the Results, “OCS” must be replaced with “OSCs”.
· In the 5th sentence of the 3rd paragraph of the Discussion, “shown” must be replaced with “found”.
· In the 3rd sentence of the last paragraph of the Discussion, “to” after “agree” must be replaced with “with”, and “to use” must be replaced with “using”.
· In the 4th sentence of the last paragraph of the Discussion, “matrices” must be replaced with “matrix”.
Markus Rövekamp
Stefan Volkenstein
Amir Minovi
Aliana Neubaur
Stefan Dazert
Mirko Aach
Thomas Armin Schildhauer
Manfred Köller
Christina Sengstock
Author Info
Corresponding Author
Christina Sengstock
Surgical Research, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany
Article Info
Article Type
Research Article
Publication history
Received: Wed 17, Jun 2020
Accepted: Wed 01, Jul 2020
Published: Wed 29, Jul 2020
Copyright
© 2023 Christina Sengstock. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.RGM.2020.02.04