Infranatant Portion of Microfragmented Adipose Tissue: A Promising Source of SVF for the Management of Androgenetic Alopecia

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for

researchers?

A: Excellent

Comments:

The word "microfragmented" should be written as a single word.

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Good

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Very good

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Good

Comments:

The contents of the headings "Background" and "Introduction" should be clubbed together.

Tools and Methods

Q: Are methods the author uses adequate and well used?

A: Very good

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Good

Comments:

This study opens the possibility to use only the infranatant component of the emulsified microfragmented adipose tissue without any need of enzymatic digestion. It further concludes that the use of microcannulas, in combination with a mechanical digestion by an emulsification procedure and centrifuge, could ease stromal vascular fraction (SVF) cell isolation for regenerative treatment and could also be performed in a medical facility. Further studies are needed to deepen the understanding of the composition of this cell population for regenerative purposes.

Literature

Q: Does the author utilize relevant literature?

A: Very good

Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Very good

Length

Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Very good

Writing style

Q: Is it clear and understandable?

A: Good

Comments:

The full forms of the abbreviations "AA" and "SVF" must be provided in the text beside where they have been first used.

Further comments on the paper

Comments: This study aims to prove the possibility to transfer a good amount of cells of the stromal vascular fraction (SVF) and adipose-derived stem cells (ADSCs) in the infranatant portion of microfragmented adipose tissue. In order to successfully introduce ADSCs into treatment plans, the study investigates a new protocol (SEFFIHAIR™) that offers the opportunity to implant successfully only the cells of the SVF. This method is not only an important step for a proper evaluation of the clinical results, but it also offers a viable option for an easy and repeatable therapy in androgenetic alopecia (AGA) treatment.

Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

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Thanks,
Science Repository Team