Directionality of Chemical Reaction and Spontaneity of Biological Process in the Context of Entropy

Review Data

Q: Is the topic relevant to the journal's area of interest? Is it contemporary and interesting for researchers?

A: Good

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Good

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Good

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Good

Tools and Methods

Q: Are the methods the author uses adequate and well used?

A: Good

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them coherent?

A: Good

Comments: The Discussion elaborates on the thermodynamic property entropy in chemical reactions. Moving ahead, the authors discussed how the errors in information transfer from DNA to RNA significantly impair gene function and lead to misfolded and poorly functioning proteins.  The Discussion further suggests that entropy represents the negative and passive side of the matter, while potential energy shows a positive and active side. In conclusion, the authors put forward the importance of predicting the directionality of reactions and how entropy plays a significant role in predicting the direction and spontaneity of the reaction.

Literature

Q: Does the author utilize relevant literature?

A: Good

Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Good

Length

Q: Is the length of the paper adequate for the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legends and notations clear?

A: Good

Writing style

Q: Is it clear and understandable?

A: Good

Further comments on the paper

Comments: The manuscript illustrates the directionality of chemical reaction and spontaneity of biological process with respect to entropy. The study further discussed the entropy in chemical reactions, living systems. The authors also highlighted the significance of macromolecules in terms of potential and entropy. 

Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

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Science Repository Team