Primary Clear Cell Sarcoma of Bone: Report of a Case Arising from Distal Femur in a Pediatric Patient and Review of the Literature

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for

researchers?

A: Good

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Good

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Good

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Good

Tools and Methods

Q: Are methods the author uses adequate and well used?

A: Good

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Good

Comments: The Discussion highlights on the literature describing the rarity of the clear cell sarcoma (CCS) from all aspects, and states that with the lack of wider clinical experience on cohort studies of patients, surgery appear as the only beneficial treatment, also new therapeutic agents and molecular targeted therapy must be implemented in order to improve the oncologic outcome both in early and late stages of the disease. Further it also suggests that extremely rare CCS of bone should be considered in the differential diagnosis of primary bone tumors.

Literature

Q: Does the author utilize relevant literature?

A: Good

Author's knowledge

Q: What is the level of author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Good

Length

Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Good.

Writing style

Q: Is it clear and understandable?

A: Good

Further comments on the paper

Comments: This case presents a 13-year-old patient with the first in the literature unusual case of clear cell sarcoma of bone arising from distal femur. Later, malignant neoplasms appeared on histological sections which was composed by nests of uniform cells separated by fibrous septa. The purpose of this case report was to find common clinical-radiological features to this rare case of clear cell sarcoma.

Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

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Science Repository Team