Necrotizing Soft-Tissue Infection and Necrotizing Fasciitis in Adults of a Single Center: Review, Current Concepts and Challenges

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for

researchers?

A: Excellent

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Very good

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Good

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Very good

Tools and Methods

Q: Are methods the author uses adequate and well used?

A: Very good

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Good

Comments:

The Discussion section emphasizes upon a meticulous physical examination and a clear understanding of the clinical picture having paramount importance in establishing an early diagnosis of necrotizing soft-tissue infection or necrotizing fasciitis (NSTI/NF). Further the polymicrobial infection identified by wound cultures comes out as the dominant cause of the condition. The review concludes that the treatment of NSTI/NF is multidisciplinary, and the mainstay of treatment entails an aggressive approach with extensive and repeated necrectomy/debridement to completely control the progressing sepsis in the soft tissues.

Literature

Q: Does the author utilize relevant literature?

A: Very good

Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Very good

Length

Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Good

Writing style

Q: Is it clear and understandable?

A: Good

Further comments on the paper

Comments: This case series aims to assess the clinical and therapeutic characteristics of patients treated for necrotizing soft-tissue infection (NSTI)/ necrotizing fasciitis (NF) and determine their outcomes. Necrotizing fasciitis is the most common type of NSTI and the most complicated and life-threatening NSTI leading to sepsis, multiple organ dysfunction/failure, and, if not timely treated, to potentially fatal outcome. The study follows a clinical diagnostic and treatment algorithm for the management of NF suspected patients and patients for whom NSTI could not be ruled out.

Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

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